On March 18, 2022, this report was posted online as an MMWR Early Release. Weekly rates among unvaccinated adults and adults who received a primary COVID-19 vaccination series with a booster or additional dose peaked at 149.8 (January 8, 2022) and 11.7 (January 22, 2022), respectively. Department of Health and Human Services. Egyptian hemodialysis patients' willingness to receive the COVID-19 PubMed Persons with multiple, unknown, or missing race accounted for 6.9% (weighted) of all cases. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. COVID-19; IL-6 . The group raised concerns about a small number of Guillain-Barre syndrome cases in vaccine recipients and wanted more data, especially on efficacy in those at highest risk. Suggested citation for this article: Taylor CA, Whitaker M, Anglin O, et al. During the Omicron dominant period, receipt of 2 doses during pregnancy reduced the risk of the infant testing SARS-CoV-2 positive by 21% (95% CI: 21, 48) during the first 2 months of life, 14% (95% CI: 8, 32) during the first 4 months of life, and 13% (95% CI: 3, 26) during the first 6 months of life (Table2). J. Obstet. COVID-19Associated Hospitalizations Among Adults During SARS-CoV-2 Delta and Omicron Variant Predominance, by Race/Ethnicity and Vaccination Status COVID-NET, 14 States, July 2021January 2022. However, these Omicron impacts have been mostly observed in countries with high vaccination rates in the Region: the comparatively lower rate of hospitalizations and deaths so far is in large part thanks to vaccination, particularly of vulnerable groups. Adults who completed a primary vaccination series were persons who had received the second dose of a 2-dose COVID-19 vaccination series or a single dose of a 1-dose product 14 days before a positive SARS-CoV-2 test associated with their hospitalization but received no booster or additional dose. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Morb. https://downloads.aap.org/AAP/PDF/AAP%20and%20CHA%20-%20Children%20and%20COVID-19%20State%20Data%20Report%209.29.22%20FINAL.pdf?_ga=2.255000394.335550773.1665001859-370326403.1636740765 (2022). JAMA Netw. Models in this analysis were adjusted for the same covariates included in the primary analysis. Rep. 70, 895899 (2021). We further classified vaccination status by the trimester within which the second dose or the unique dose (for those who received only one dose) was received. They help us to know which pages are the most and least popular and see how visitors move around the site. Hospitalizations rates increased among all adults irrespective of vaccination status (unvaccinated, primary series only, or primary series plus a booster or additional dose). Data among adults over 50 showed that a booster shot gave even stronger protection. Vaccination offers the best way to protect against COVID-19 and its complications. It is critical that nursing home residents stay up to date with CO VID-19 vaccines and receive a bivalent booster dose to maximize protection against COVID-19. By clicking Sign up, you agree to receive marketing emails from Insider Marks, K. J. et al. Correspondence to Ann Intern Med 2021;174:140919. Graff, K. et al. N. Engl. They, as well as vaccinated people who are immunocompromised and at higher risk of severe COVID-19, are still vulnerable to being infected by a vaccinated person. Zerbo, O. et al. N. Engl. Most mothers (66.14%) were between ages 25 and <35 years, and more than a quarter (27.27%) were of Asian race, 5.16% were Black, 24.44% were of Hispanic ethnicity and 37.57% were White. 226, 236 e1236.e14 (2022). TN, NMF, SFlax, MC, DDA, AMP, and ST conceptualised the work. Because the immune status of all patients is not known, an additional dose (recommended for persons with a weakened immune system) cannot be distinguished from a booster dose. Clinical trends among U.S. adults hospitalized with COVID-19, March to December 2020: a cross-sectional study. Without the vaccines many more people would likely be in hospital. We thank staff at UKHSA and members of the UK Government SPI-M committee and the UKHSA Variant Technical Group for valuable discussions. During the study period, the omicron variant experienced a rapidly increasing incidence, whereas the delta variant was experiencing a decreasing or less rapidly increasing incidence. J. But the average . pdf files, Omicron: fewer adverse outcomes come with new dangers, Statement on offensive historical content, Redistribute or republish the final article, Reuse portions or extracts from the article in other works. Provided by the Springer Nature SharedIt content-sharing initiative. Nature. Hospitalization rates during peak Omicron circulation (January 2022) among unvaccinated adults remained 12 times the rates among vaccinated adults who received booster or additional doses and four times the rates among adults who received a primary series, but no booster or additional dose. Severe cases may increase in the wake of holiday parties where people of all ages mixed. Dis. SARS-CoV-2 infections can result in COVID-19associated hospitalizations, even among vaccinated persons. The population of unvaccinated adults is determined by subtracting the number of adults who received any dose of vaccine, as previously defined, from the population. NMF, MC, GD, DDA, AMP, and ST handled project administration. Effectiveness of Two Doses of BNT162b2 Vaccine before and during Proxy Omicron Period. According to the Ontario Science Table's online dashboard, the hospital occupancy rate for the unvaccinated was 611 per million unvaccinated people in the province's population as of Jan. 7,. Taken together, these findings suggest that the increased risk for hospitalization among Black adults during the Omicron-predominant period might also be due, in part, to lower proportions of Black adults receiving both the primary vaccination series and booster doses. The images or other third party material in this article are included in the articles Creative Commons license, unless indicated otherwise in a credit line to the material. Hobbs, C. V. et al. Mortal. J. Pediatr. According to the CDC, hospitalization rates among the unvaccinated were 16 times higher in December overall. Symptoms are abstracted from the medical chart and might not be complete. If material is not included in the articles Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Among nonpregnant and pregnant adults aged 18 years, hospitalization rates were calculated overall, and by race/ethnicity and COVID-19 vaccination status. Includes current treatment or recent diagnosis within the previous 12 months of an immunosuppressive condition or use of an immunosuppressive therapy. 387, 227236 (2022). Thompson, M. G. et al. Omicron Is Not More Severe for Children, Despite Rising Hospitalizations More children are being treated for Covid, but a combination of factors, including low vaccination rates, most. Pre-Omicron versions of Covid, in. To ensure stability and reliability of rates by vaccination status, data are presented beginning when 14 days have passed since at least 5% of the population of adults aged 18 years in the COVID-NET surveillance catchment area had received an additional or booster dose. The stats are for COVID-associated hospitalizations, which may include people for whom COVID-19 was not the primary reason for admission. Christopher A. Taylor, PhD1; Michael Whitaker, MPH1; Onika Anglin, MPH1,2; Jennifer Milucky, MSPH1; Kadam Patel, MPH1,2; Huong Pham, MPH1; Shua J. Chai, MD3,4; Nisha B. Alden, MPH5; Kimberly Yousey-Hindes, MPH6; Evan J. Anderson, MD7,8,9; Kenzie Teno, MPH10; Libby Reeg, MPH11; Kathryn Como-Sabetti, MPH12; Molly Bleecker, MA13; Grant Barney, MPH14; Nancy M. Bennett, MD15; Laurie M. Billing, MPH16; Melissa Sutton, MD17; H. Keipp Talbot, MD18; Keegan McCaffrey19; Fiona P. Havers, MD1; COVID-NET Surveillance Team (View author affiliations). N. Engl. These persons are excluded from the proportions of race/ethnicity but are included in other analyses. No other exclusion criteria were applied. Infect. RESP-NET: COVID-19 Associated Hospitalization Rates among Adults Ages 65 Years and Older CDC's Respiratory Virus Hospitalization Surveillance Network (RESP-NET) shows that overall weekly rates of COVID-19-associated hospitalizations have declined for all age groups from a peak in December 2022. NEW YORK and MAINZ, GERMANY, March 1, 2023 Pfizer Inc. (NYSE: PFE) and BioNTech SE (Nasdaq: BNTX) today submitted an application to the U.S. Food and Drug Administration (FDA) for Emergency Use Authorization (EUA) of a booster (fourth) dose of the companies' Omicron BA.4/BA.5-adapted bivalent COVID-19 vaccine in children 6 months through 4 years of age (also referred to as under 5 years). It showed that boosters further reduced the risk of hospitalization. Abbreviations: COVID-NET = COVID-19Associated Hospitalization Surveillance Network; ICU=intensive care unit; IMV=invasive mechanical ventilation; LTCF=long-term care facility; NA = not applicable. The difference between the two studies might be due to population characteristics and the timing of follow-up as ours went through May 31, 2022, while the Norwegian study ended in April 2022. References to non-CDC sites on the Internet are State data show the average age for COVID deaths was about 80 in late 2020, but dropped in spring 2021 to as low as 69 after most older adults received their first COVID vaccines. We also conducted analyses based on the trimester during which the vaccine was received during pregnancy (first, second, or third trimester). https://www.medrxiv.org/content/10.1101/2021.08.27.21262356v1 Gretchen Rothrock, California Emerging Infections Program; Millen Tsegaye, Colorado Department of Public Health and Environment; Julie Plano, Connecticut Emerging Infections Program, Yale School of Public Health; Kyle Openo, Georgia Emerging Infections Program, Georgia Department of Public Health Division of Infectious Diseases, School of Medicine, Emory University; Andy Weigel, Iowa Department of Health; Chloe Brown, Michigan Department of Health and Human Services; Erica Bye, Minnesota Department of Health; Wickliffe Omondi, New Mexico Emerging Infections Program, University of New Mexico; Alison Muse, New York State Department of Health; Christina Felsen, University of Rochester School of Medicine and Dentistry; Eli Shiltz, Ohio Department of Health; Nasreen Abdullah, Public Health Division, Oregon Health Authority; William Schaffner, Vanderbilt University Medical Center; Melanie Crossland, Salt Lake County Health Department. Shook, L. L. et al. During the Omicron dominant period, maternal vaccination with at least two doses reduced the infants risk of testing SARS-CoV-2 positive by 43% (95% CI: 4, 69) during the first 2 months of life, 36% (95% CI:11, 55) during the first 4 months of life, and 41% (95% CI: 25, 53) during the first 6 months of life (Supplemental Table2). Hospitalization rates among non-Hispanic Black adults increased more than rates in other racial/ethnic groups. Risk of hospitalization and vaccine effectiveness among COVID-19 O.Z. As with previous variants, being vaccinated greatly protects you from severe disease with omicron. as well as other partner offers and accept our. This conversion might result in character translation or format errors in the HTML version. Thank you for visiting nature.com. SGN, HHW, NA, WH, MK, PB, AZ, JLB, MC, NAA, KH, RH, AC, GD, and ST curated the data. During the period of Omicron predominance, hospitalization rates increased most sharply among Black adults in the United States relative to all other racial and ethnic groups examined and reached the highest rate observed among all racial and ethnic groups since the beginning of the pandemic. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. In the US, as of the end of September 2022, almost 15 million children ages <18 years have tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes Coronavirus Disease 2019 (COVID-19). All adjustment variables were selected a priori based on prior work36. MMWR and Morbidity and Mortality Weekly Report are service marks of the U.S. Department of Health and Human Services. We calculated vaccine effectiveness (VE) as 100% multiplied by 1HR. How likely is COVID-19 hospitalization for vaccinated Americans? - USAFacts Fully-vaccinated in this chart meant one dose of the J&J vaccine or two doses of Pfizer or Moderna. Nat Commun 14, 894 (2023). Vaccinated patients during the Delta wave were 37% (over with two doses), while during the Omicron wave they were 57%. This is consistent with data showing the incidence of positive SARS-CoV-2 test results or death from COVID-19 is higher among unvaccinated adults and adults who have not received a booster than among those who have received a booster or additional dose (5). wrote the initial manuscript. Mortal. E.L. coordinated administrative tasks. Rep. 7, 255263 (2022). "People who get vaccinated may be more cautious about COVID in general, or perhaps getting vaccinated makes them less cautious, or they may live in states with more/less COVID risk, etc," Jit said. Between December 15, 2020, and May 31, 2022, we identified 62,117 infants born at Kaiser Permanente Northern California (KPNC), an integrated healthcare delivery organization. Models were adjusted for the covariates listed above. Study finds Omicron hospital risk 10 times higher in unvaccinated E. & Klein, N. P. Effectiveness of vaccination during pregnancy to prevent infant pertussis. We observed that infants protection through vaccination during pregnancy decreased as they aged from 2 months to 6 months. JAMA 326, 16291631 (2021). Overall, the study results support recommendations for vaccination during pregnancy to protect both mothers and their infants. It is possible that our exclusion criteria may have resulted in a final sample that may not be reflective of all KPNC infants. During the first 6 months of life, 940 (3.10%) infants tested positive for SARS-CoV-2 by polymerase chain reaction (PCR) test and 10 (0.03%) infants were hospitalized with a positive SARS-CoV-2 test. MMWR Morb Mortal Wkly Rep 2022;71:1328. Mortal. COVID-NET conducts population-based surveillance for laboratory-confirmed COVID-19associated hospitalizations in 99 counties across 14 states. COVID-19associated hospitalizations are those occurring among residents of a predefined surveillance catchment area who have a positive real-time reverse transcriptionpolymerase chain reaction (RT-PCR) or rapid antigen detection test result for SARS-CoV-2 during hospitalization or the 14 days preceding admission. KPNC has a comprehensive electronic health record system (Kaiser Permanente HealthConnect, a customized EPIC system), that captures detailed information on all medical services, including immunization, membership enrollment including place of residence, demographics, and pregnancy-related care from pregnancy onset to delivery, and beyond. Evaluation of acute adverse events after Covid-19 vaccination during pregnancy. 9-14 As of October 2022, 68% of the US population has completed primary series vaccination. Infants were followed from birth until the first positive SARS-CoV-2 test by PCR at age 2, 4, or 6 months, with censoring due to death, health plan disenrollment, or end of follow-up (May 31, 2022).