By submitting a comment you agree to abide by our Terms and Community Guidelines. It is generated automatically, and you can download, view, and share it at any time. 1c and Extended Data Fig. Her YouTube channel offers tips on productivity hacks, resume evaluations, data science employment, and more. Single-stranded DNA libraries were built from 30l of DNA extract in the absence of uracil DNA glycosylase (ss_nonUDG) followed by double indexing, using an automated version of the protocols described in61 on the liquid handling system mentioned before. In the meantime, to ensure continued support, we are displaying the site without styles & Posth, C. Latest trends in archaeogenetic research of west Eurasians. The latter was created as a support network for women in the industry to discuss, share, and learn from each other.. Check out The data science resume that got me my FAANG job and subscribe to Tina Huangs YouTube channel. The MDS analysis showing the genetic affinity among European hunter-gatherers was based on the distance matrix derived from outgroup f3-statistics, in the form 1f3(Mbuti.DG; pop1, pop2) and performed with classical MDS algorithm (cmdscale) implemented in R 3.5.1. PubMed Central The mitochondrial haplogroups were determined using HaploGrep 295, based on the consensus sequences generated from Schmutzi inspected for each sample at increasing quality filters (from q0 to q20). Rivollat, M. et al. In addition to her rich experience, including bioinformatics cancer research at OICR, Tina is a popular YouTuber with over 60K subscribers. Dots are maximum likelihood estimates and error bars show 95% confidence intervals of the derived allele frequencies (n, the number of individuals in each group, is provided in Supplementary Data 3.G). Even better your perks will stay yours even after you complete the course. Tina Huang. If youd like to learn more about data science, transitioning into computer science, and software engineering, you can also subscribe to my YouTube channel. Int. 62, 3643 (2020). Nature 592, 253257 (2021). I have been watching Tina's YouTube channel's videos since the past month and find her explanations / reviews very useful and actionable and being in Toronto myself I think it will be same contextually when I start applying for DSc jobs (and make the big switch from Healthcare that I am in currently). 5). Skoglund, P. et al. Using DATES software, we estimated the admixture between Villabruna/Oberkassel and ANE ancestries in these old Sidelkino-cluster-related individuals to around 1513ka (Extended Data Fig. This was confirmed with qpAdm, in which we could model all individuals from the Oberkassel cluster as a broadly constant mixture of approximately 75% Arene Candide 16 and 25% Goyet Q-2 (or 90% Arene Candide 16 and 10% Fournol 85) (Fig. We then attempted to model 250 published and newly reported hunter-gatherers dated to 145ka using qpAdm as a mixture of Oberkassel, Sidelkino, GoyetQ2 ancestries, and an ancestry maximized in Anatolian Neolithic farmers (ANF), as a considerable portion of the sequenced hunter-gatherer genomes date after around 8ka, when ANF ancestry started spreading across Europe. Each aDNA library was double indexed60 in 14 parallel 100l reactions using PfuTurbo DNA Polymerase (Agilent). Limits of long-term selection against Neandertal introgression. The expansion of farming by9,8, 7.5 and7 kais shown as green shades. The nucleolus is the largest substructure in the nucleus, where ribosome biogenesis occurs. 2010, pdb.prot5448 (2010). After the LGM, the Epigravettian culture was widespread in southern andsoutheastern Europe. Dismiss. Edit your profile. The competition is based on a pretty strict data set thats been collected by the Stanford Computer Science department. In the box plot the centre line is the median, box bounds delineate the interquartile range and whiskers extend to maximum and minimum values, excluding outliers. Tina Huang is a Data Scientist at a FAANG (Facebook, Amazon Apple, Netflix, Google) company. Big Data, Data Mining, and Machine Learning (Jared Dean) . We further validated the genetic distinction between the Vstonice and Fournol clusters observed in the MDS plot with a series of f4-statistics (Supplementary Data 2.B). 7, eabd6535 (2021). For the placement of individuals onto a Y-chromosomal phylogenetic tree (Extended Data Fig. A software engineer who now works as a content creator full-time, Mayuko Inoue runs a YouTube channel dedicated to software engineering, working in the tech industry, and life in general. Fu, Q. et al. 1) we used MUSCLE (-maxiters 2)96 to create a multiple genome alignment of previously published sequences and newly reported mtDNA consensus sequences with q20 according to defined thresholds (minimum average coverage >5-fold, contamination estimate <20%, HaploGrep2 haplogroup assignment consistent with manual assignment). 9; the entire IT and laboratory teams at the Department of Archaeogenetics of MPI-SHH for technical assistance; M. Meyer and S. Nagel for support with single-stranded library preparation; K. Post, P. van Es, J. Glimmerveen, M. Medendorp, M. Sier, S. Dikstra, M. Dikstra, R. van Eerden, D. Duineveld and A. Hoekman for providing access to human specimens from the North Sea (The Netherlands); M. D. Garralda and A. Estalrrich for providing access to human specimens from La Riera (Spain); J. Grski andM. Zajcfor providingaccess tohuman specimensfromMaszycka cave;C. Di Patti for providing access to human specimens from San Teodoro 2 (Italy); P. Blaeviius for providing access to the Donkalnis human remains and the new radiocarbon dates; the Italian Ministry of Culture and Soprintendenza Archeologia Belle Arti e Paesaggio for the Provinces of Verona, Rovigo, and Vicenza for granting access to the human remains of Tagliente 2; F. Fontana, who carries out investigations of the Riparo Tagliente site (Italy); the Friuli Venezia Giulia Superintendency for providing access to the human tooth Pradis 1; and the Soprintendenza Archeologia Belle Arti e Paesaggio for the Provinces of Barletta-Andria-Trani and Foggia for providing access to the Paglicci human remains. Tina Huang is a prominent data scientist, previously working at a FAANG company, and has been an active YouTuber, creating data science content for nearly a decade. Youll be surprised how much value there is in a quick XGBoost model, for example. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. The purified products were amplified in multiple 100l reactions using Herculase II Fusion DNA Polymerase (Agilent) following the manufacturers specifications with 0.3M of the IS5/IS6 primers. During this time agriculture and a sedentary lifestyle spread from Anatolia to Europe. SDS 563: How to Rock at Data Science with Tina Huang Saag, L. et al. Science 360, eaar7711 (2018). Imbalanced aspect categorization using bidirectional encoder Twelve-month follow-up after hospitalization for SARS-COV-2: physiology Nat. Low latency, reasonably low communication overhead and ability to support real time applications are the reasons for . Tina Huang is a well-known data scientist who has over 10 years of experience on YouTube and has previously worked at a FAANG organization. B. et al. 4). Trzej niedwiedzi braciszkowie przeywaj swoje dziecistwo, pakujc si w najrozmaitsze tarapaty za spraw magicznego pudeka. 31, 24842493.e7 (2021). She has been working for the data sciences industry since 2014. ADS This figure shows (a) the distribution of and interaction between hunter-gatherer genetic ancestries and (b) a simplified schematic representation of major chrono-cultural subdivisions of the European Upper Palaeolithic (green blocks) followed by a grouped Mesolithic to Neolithic block (in gray). Advanced Science: Vol 10, No 7 - onlinelibrary.wiley.com It can take several minutes for a query to complete, and if youre using a lot of data the whole table may be locked up. Thank you for visiting nature.com. Rep. 11, 15005 (2021). A similar pattern is observed through the analysis of ROH segments (Extended Data Fig. This genetic signature is shared among individuals associated with the archaeologically defined Gravettian culture (3326ka) in central and southern Europe and seemingly disappeared after the Last Glacial Maximum4 (LGM). "With these findings, we can for the first time directly support the hypothesis that during the Last Glacial Maximum people found refuge in the climatically more favourable region of southwestern Europe" says first author Cosimo Posth. If material is not included in the articles Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Data science is a lot like cooking. Adv. 4. Bioinformatics 29, 16821684 (2013). Charlene Hunter is a developer and an incredible advocate for increasing diversity in tech. Tina_Huang_Resume_i.pdf - Tina Huang hellotinah@gmail.com Unlike setting up a Premium subscription to our platform, for which you would be billed monthly or annually, acquiring individual courses requires a one-time payment only. It is often considered as a pan-European cultural mosaic with regional variations in material to symbolic productions20,21. The more information you have the more data you need to analyze and make your predictions. Palma di Cesnola, A. Questions? The Kostenki genetic signature (related to the Kostenki 14 genome, and hereafter referred to as the Kostenkicluster or ancestry) contributed to the later Vstonice genetic cluster(hereafter,Vstonice cluster or ancestry), named after the Doln Vstonice site in Czechia4. The genetic prehistory of the Baltic Sea region. 4 and Supplementary Data 3.C). Here we will provide you only interesting content, which you will like very much. ), no. Mol. Nature 615, 117126 (2023). Tina Huang - Senior Tax Analyst - Lion | LinkedIn About the Instructor. Nat. Nature 514, 445449 (2014). PubMed 2014-2020.4.01.16-0030) and C.L.S. "Presumably, these people came from the Balkans, arrived first in northern Italy around the time of the glacial maximum and spread all the way south to Sicily.". From around 8ka, we begin to observe admixture events with Sidelkino ancestry in central Europe. Ideally, we also want lots of data because this will give us more confidence in our results. Ecol. 27, 32023208.e9 (2017). Track your course progress, set daily goals, and make success a routine. Otte, M. Appearance, expansion and dilution of the Magdalenian civilization. Data Visualization Explained: Candlestick Chart, R Programming for Statistics and Data Science 2020. Google Scholar. Besides, the nucleolus is involved in a variety of cellular functions including cell cycle regulation and cellular stress response. 14 following. . Corporate Financial Managementspring term (BS 2508) Second year of undergraduate. 17, 60 (2016). This figure shows that the Gravettian-associated individuals from western Europe (Fournol cluster) are closely related to Goyet Q116-1 while the Gravettian-associated individuals from central-eastern and southern Europe (Vstonice cluster) are closely related to the Sunghir group, representative of the Kostenki cluster. The responsible co-authors for the material from each archaeological site are listed in Supplementary Information, section 1. Jobs People Learning Dismiss Dismiss. 724703 and no. 4, 11 (2007). I love learning new things a. Sign In Create Free Account. Biol. CNRS, MNHN, Universit de Paris Cit, Muse de lHomme, Paris, France, PALEVOPRIM Lab UMR 7262 CNRS-INEE, University of Poitiers, Poitiers, France, Centre de Valorisation des Collections Scientifiques, Universit de Poitiers, Mignaloux Beauvoir, France, Muses de PoitiersVille de Poitiers, Poitiers, France, Departamento de Geologa, Facultad de Ciencia y Tecnologa, Universidad del Pas Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), Leioa, Spain, Sociedad de Ciencias Aranzadi, Donostia-San Sebastian, Spain, Centro UCM-ISCIII de Investigacin sobre Evolucin y Comportamiento Humanos, Madrid, Spain, Institute of Archaeology, University of Rzeszw, Rzeszw, Poland, Foundation for Rzeszw Archaeological Centre, Rzeszw, Poland, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA, Department of Psychiatry, Harvard Medical School, Boston, MA, USA, Groninger Instituut voor Archeologie, Groningen University, Groningen, The Netherlands, Institute of Archaeology and Ethnology, Polish Academy of Science, Pozna, Poland, Institute of History, Archaeology and Ethnography, Dushanbe, Tajikistan, ArchaeoZOOlogy in Siberia and Central AsiaZooSCAn, CNRSIAET SB RAS International Research Laboratory, IRL 2013, Institute of Archaeology SB RAS, Novosibirsk, Russia, Research Institute and Museum of Anthropology, Moscow State University, Moscow, Russia, Grupo de I+D+i EVOADAPTA (Evolucin Humana y Adaptaciones durante la Prehistoria) Departamento de Ciencias Histricas, Universidad de Cantabria, Santander, Spain, Borja Gonzlez-Rabanal,Ana B. Marn-Arroyo&Lawrence G. Straus, Instituto Internacional de Investigaciones Prehistricas de Cantabria (IIIPC), Universidad de Cantabria-Gobierno de Cantabria-Banco Santander, Santander, Spain, Departamento de Biologa de Organismos y Sistemas, Universidad de Oviedo, Oviedo, Spain, Quaternary Environments and Humans, OD Earth and History of Life, Royal Belgian Institute of Natural Sciences, Brussels, Belgium, Caroline Polet,Ivan Jadin&Sbastien Villotte, Muses Royaux dArt et dHistoire, Bruxelles, Belgium, Institute of Historical Research, University of Girona, Catalonia, Spain, Joaquim Soler,Neus Coromina&Isaac Ruf, INRAP/UMR 8215 Trajectoires 21, Paris, France, School of Human Evolution and Social Change, Arizona State University, Tempe, AZ, USA, Department of Anthropology, University of New Mexico, Albuquerque, NM, USA, GoArchPal-GoArchon, Viville sous-les-Cotes, France, Archologie & Mnzkabinett, Universalmuseum Joanneum, Graz, Austria, Museum Das Dorf des Welan, Wllersdorf-Steinabrckl, Austria, Department of Humanities, University of Ferrara, Ferrara, Italy, National Museum of Antiquities, Leiden, The Netherlands, Faculty of Archaeology, Leiden University, Leiden, The Netherlands, Biogeology, Department of Geosciences, University of Tbingen, Tbingen, Germany, Unit de Recherches Art, Archologie Patrimoine, Universit de Lige, Lige, Belgium, I.U. iScience 25, 104244 (2022). Archaeological background, method descriptions and discussions additional to the main text, including sections 113, Figs. STOC 2023: Accepted Papers Schubert, M., Lindgreen, S. & Orlando, L. AdapterRemoval v2: rapid adapter trimming, identification, and read merging. . 18 and Supplementary Data 2.O), suggests the Balkans as a source of the incoming Epigravettian-associated population. Li, H. & Durbin, R. Fast and accurate short read alignment with BurrowsWheeler transform. You are using a browser version with limited support for CSS. The admixture graph shows that the Bacho Kiro IUP group (n=3) shares ancestry with multiple early modern human lineages2 (Supplementary Information, section7), and that the more than 45,000-year-old Zlat k genome1 is the most deeply divergent non-African lineage sequenced to date (Extended Data Fig. Hi! It encourages me to go out and re-learn SQL and excites me for the mock interviews to come. Metadata information of studied individuals. 116, 105100 (2020). Overall, the Solutrean-associated Le Piage II individual links the preceding Fournol ancestry with the succeeding ancestry found in El Mirn, providing direct evidence for genetic continuity throughout the LGM in southwestern and western Europe. Proc. Mayra Alexandra Castrosqui - Quantitative Analyst - LinkedIn Utilized python and R on high performance computing Linux cluster to discover 3 new cancer mutations. Stephen Kaye Alberto en LinkedIn: Future of Data and AI | Data Science Dojo Don't be shy, get in touch. Natl Acad. Publications 4. h-index 3. 132, Tables 14 and references. Admixture events were dated using the ancestry covariance pattern-based DATES 753 program105, with a bin size of 0.1 cM for covariance calculation and the start of exponential fitting at d0.5cM. Subsequently, I worked in bioinformatics for a year and then did my Master's in computer science (MCIT) at the University of Pennsylvania. H. Rougier and I.C. This free online conference is featuring panel discussions from The ancient human specimens analysed in this work derive from multiple scientific collaborations. As a Graduate and Consultant in the Business Tax Advisory (Financial Services) team, I provided tax advice and tax compliance services to organisations in the banking and capital markets, wealth and . We built a Maximum Parsimony tree with 103 mtDNA sequences plus an African sequence as the outgroup (not shown) after the removal of individuals younger than 6.5ka and mtDNAs from the same site with an identical placement. Kozowski, J. K. The origin of the Gravettian. Genetic ancestry changes in Stone to Bronze Age transition in the East European plain. Then the cleaned reads together with cleaned reads from 1240k capture sequencing were mapped to human reference mitochondrial sequence NC_012920.1 with BWA 0.7.12 aln/samse algorithm (parameters n 0.01, l 16500) and realigned with CircularMapper64. It will provide you with confidence and methodology for demonstrating the required skills appropriately. Develped strategies for promoting G-Mark to Taiwan. I hold a Bachelor's degree at the University of Toronto where I studied pharmacology. ContamLD: estimation of ancient nuclear DNA contamination using breakdown of linkage disequilibrium. C.L.S. Tina Huang - Age, Family, Bio | Famous Birthdays Christina Yu-Ting Wang - Design Team Lead - TomTom | LinkedIn However, one of my favorites is using supervised learning techniques, such as random forest, SVM, and XGBoost, to discover which features contribute the most to the success of a product. The idea of data warehousing is to store large amounts of data in a way that makes it easier to extract and analyse. A. Stoessel performed CT scanning and advised on sampling strategy. The authors declare no competing interests. In our case, we had data about people who had fallen off the internet, and we wanted to predict the probability that they would fall off at a certain time. Hunter-gatherers across the great Adriatic-Po region during the Last Glacial Maximum: environmental and cultural dynamics. 41 Year Olds. Since she graduated, shes been working at a company that develops software for the Windows operating system. In product development, we do lots of opportunity sizing to decide which features to build and what opportunities to invest in. Tina started her YouTube channel in 2020. View Tina Huang's profile on LinkedIn, the world's largest professional community. The research team describes a large-scale genetic replacement that may have been caused, in part, by climatic changes that forced people to migrate: "At that time, the climate warmed up quickly and considerably and forests spread across the European continent. The Gravettian from a palaeodemographic point of view. Jagwire Europe - Fevacom NV . Ancient genomes from present-day France unveil 7,000 years of its demographic history. Earlier I had practiced a bit of MySQL, but here through this course I got introduced to PostgreSQL. Genomic diversity and admixture differs for stone-age Scandinavian foragers and farmers. Hunter-gatherers carrying an admixed WHG/EHG genetic profile have been sequenced from various regions of northern and eastern Europe, raising the question of how these two types of ancestries formed and interacted with each other through time and space37,38,39,40. 8). Tina Huang - Instructor | 365 Data Science Protoc. 35, 15471549 (2018). Well be back on Friday so, if youre not already, get subscribed to the Brandwatch Bulletin right away. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. In conclusion, our study reveals that western and southwestern Europe served as climatic refugia for the persistence of human groups during the coldest phase of the last Ice Age whereas populations in the Italian peninsula and the eastern European plain were genetically overturned, challenging the role of these regions as glacial refugia for humans. 3b). Human bones and teeth were sampled in clean room facilities to minimize the inclusion of modern human DNA contamination during this procedure. Rev. Error bars show 1s.e.m. B 370, 20130624 (2015). I am attending the Future of Data and AI by Data Science Dojo on March 1st and 2nd, 2023. Nat. 1). Tina Huang - Climate & Environment Knowledge Analyst - LinkedIn Previous studies identified two different genetic compositions in Magdalenian-associated individualsthe GoyetQ2 cluster including central-western European genomes dated to around 15ka (from France, Belgium and Germany), and the ancestry of the El Mirn individual from Spain4,14 from around 19ka. The 3 Greatest Moments in science library uga hours History, Addicted to hills science diet adult small bites? Article Google Scholar. Genome sequence of a 45,000-year-old modern human from western Siberia. The Villabruna ancestry later appeared in central Europe and it is thought to have largely replaced groups related to the GoyetQ2ancestry4.